Dietary soy improves glycaemic control and promotes weight loss in women with polycystic ovary syndrome

The effect of dietary soy intake on weight loss, glycaemic control, lipid profiles and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomised clinical trial

Karamali et al., JHND Early View Unknown


The present study aimed to evaluate the effects of dietary soy intake on weight loss and metabolic status of patients with polycystic ovary syndrome (PCOS).


A randomised clinical trial was conducted among 60 women with PCOS. Participants were randomly assigned into two groups to receive either a test diet (n = 30) or a control diet (n = 30) for 8 weeks. Participants in the test group consumed a diet containing 0.8 g protein kg–1body weight (35% animal proteins, 35% soy protein and 30% vegetable proteins) and participants in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins.


Adherence to the test diet, compared with the control diet, resulted in significant decreases [mean (SD)] in body mass index (BMI) [−0.3 (0.6) versus +0.1 (0.5) kg m–2, = 0.02], fasting plasma glucose [−0.2 (0.5) versus +0.1 (0.3) mmol L−1, = 0.01], total testosterone [−0.3 (0.7) versus +0.3 (0.3) mmol L−1, < 0.001], insulin [−15.0 (18.0) versus +4.8 (18.6) pmol L−1, < 0.001] and insulin resistance [−0.6 (0.6) versus +0.2 (0.7), < 0.001], as well as a significant increase in quantitative insulin sensitivity check index [+0.01 (0.01) versus −0.002 (0.02), = 0.01]. In addition, significant decreases in triglycerides [−0.1 (0.4) versus +0.2 (0.3) mmol L−1, = 0.01] and malondialdehyde (MDA) [−1.2 (1.0) versus +0.2 (1.2) μmol L−1, < 0.001] and significant increases in nitric oxide (NO) [+13.6 (14.1) versus +0.9 (24.3) μmol L−1, = 0.01] and glutathione (GSH) [+170.1 (175.5) versus +24.2 (168.7) μmol L−1, = 0.002] were seen in the test group compared to the control.


Adherence to test diet among subjects with PCOS significantly decreased BMI, glycaemic control, total testosterone, triglycerides and MDA, and significantly increased NO and GSH compared to the control diet.

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